Irish immigrant Katie O’Connor and her younger sister, Shannon, risk everything to journey to America at the turn of the twentieth century. As each woman passes into an intimidating, stirring, and unpredictable New York City, she is forced to rethink her dream of a better life. It isn’t until Katie begins serving the sick in the depressed slums of the Bowery alongside Dr. Titus Brentwood that she discovers her true calling. Meanwhile, fate directs the vulnerable Shannon down an unsettling path that could put her life at risk.

As Katie’s and Ty’s selflessness and devotion turn into something deeper, Ty must make a choice that could save one O’Connor sister at the expense of losing the other. But Katie hasn’t come this far to let go now. She’ll do anything to save Shannon and hold on to the man she’s come to love.