The sisters Grimm, intrepid detectives of fairy-tale crime, come face to face with their parents' kidnappers, the mysterious organization of Everafters who call themselves The Scarlet Hand. One of them turns out to be the world's most famous fairy-tale character and the other an unstoppable killing-machine known as the Jabberwocky. Without Mr. Canis (aka The Big Bad Wolf) fighting at their side, the girls have little hope that they'll be reunited with their mother and father.

That is until their long-lost Uncle Jake returns home with stories of a weapon, now destroyed, that can kill the Jabberwocky. The girls must find the pieces so the deadly blade can be reforged, and in the process butt heads with some of the most powerful Everafters in Ferryport Landing. Will the sisters Grimm save the day?