In the middle of a New Year's Eve blizzard, the staff and patients of Angels of Mercy Hospital are held hostage by armed gunmen.

Their target is Dr. Gina Freeman, who is holding vigil over her wounded fiancé, Detective Jerry Boyle. Stranded outside the hospital is ER physician Linda Fiore, whose past holds the secret the hitmen are willing to kill for. With the cold-blooded killers in control, no one may live to see the New Year.