The story opens in the shadow of the new World Trade Center, on July 4, 1976, when students George and Anna meet on the weed- and wine-fueled night of the nation’s Bicentennial celebration. George, haunted by his upbringing, instantly falls for the sensual, magnetic Anna. Soon, they couple up, dropping acid, swapping music, exploring the city and each other. Yet their romance is short-lived, and they go their own ways.

Passaro chronicles the next four decades, following George and Anna through their various relationships, their sex lives both youthful and mature, their failed marriages, and the travails of parenthood and their careers. Yet as the years go by one thing remains constant: the former lovers wonder what happened to each other. Finally, miraculously, they reconnect as the new century is beginning, only to discover that history itself will have a say in whether they can stay together.