Thirty years later, something is wrong with Spence. The Great Man can’t concentrate; he falls asleep reading The New York Review of Books. With their daughter, Sarah, away at medical school, Pru must struggle on her own to care for him. One day, feeling especially isolated, Pru meets a man, and the possibility of new romance blooms. Meanwhile, Spence’s estranged son from his first marriage has come back into their lives. Arlo, a wealthy entrepreneur who invests in biotech, may be his father’s last, best hope.