Rick Cahill is finally living a settled, happy life. His fiancée, Leah Landingham, is pregnant with their first child and he is doing PI work that pays well and keeps him out of danger. Then a doctor gives him the bad news about the headaches he's been suffering—CTE, the pro football disease that leads to senility and early death—a secret he keeps from Leah and his best friend Moira MacFarlane.

When Moira asks him to monitor her son, Luke—who's broken a restraining order to stay away from his girl-friend—a simple surveillance explodes into greed, deceit, and murder. Luke goes missing, and Rick's dogged determination compels him to follow clues that lead to the exploration of high finance and DNA cancer research.

Ultimately, Rick is forced to battle sadistic killers as he tries to find Luke and stay alive long enough to see the birth of his child.