London, 1913—the era of Sherlock Holmes, Dracula, and the Invisible Man. A time of shadows, secret societies, and dens filled with opium addicts. Into this world comes the most fantastic emissary of evil society has ever known... Dr. Fu-Manchu.

The insidious doctor returns to Great Britain with his league of assassins, the dreaded Si-Fan. He seeks to subvert the realm at the highest levels, but Fu-Manchu has his own secrets—which he will protect by any means.