The Industrial Revolution has escalated into all-out warfare. Sixteen years have passed since the Heterodyne Boys, benevolent adventurers and inventors, disappeared under mysterious circumstances. Today, Europe is ruled by the Sparks, dynasties of mad scientists ruling over - and terrorizing — the hapless population with their bizarre inventions and unchecked power, while the downtrodden dream of the Heterodynes’ return.

At Transylvania Polygnostic University, a pretty, young student named Agatha Clay seems to have nothing but bad luck. Incapable of building anything that actually works, but dedicated to her studies, Agatha seems destined for a lackluster career as a minor lab assistant. But when the university is overthrown by the ruthless tyrant Baron Klaus Wulfenbach, Agatha finds herself a prisoner aboard his massive airship Castle Wulfenbach — and it begins to look like she might carry a spark of Mad Science after all.