Summoned to relieve destroyers that are bogged down by escort duty in the escalating Pacific Theater, the Holland is met with a rather cold reception. In the eyes of Pacific Fleet sailors, North Atlantic convoy duty pales in comparison to the bloody, carrier-sinking battles of Savo Island and Guadalcanal. However, Atlantic Fleet ships have had to specialize in one thing: anti-submarine warfare.

The Holland is sent off into remote South Pacific operating areas with orders to find and destroy Japanese submarines—but with little expectation of success. Her commanders take the mission literally; using radio intercepts that are being ignored at higher levels, they determine that the Japanese have set up a 1000-mile-long picket line of six submarines, an entire squadron's worth, to act as a moveable barrier against the expected American advance into the next set of islands. These submarines are poised to sink every American aircraft carrier and destroyer and to change the course of the war.