After less than a year in Ballybucklebo, Barry Laverty is settling into the village, and with only a few more months to go before he becomes a full partner in Dr. O'Reilly's medical practice, Barry's looking forward to becoming a fixture in the community. But an unexpected romantic reversal gives him second thoughts. As much as Barry enjoys the rough and tumble of life in County Down, is tending to routine coughs and colds in a humble G.P.'s shop all he wants out of life?

Doctor Fingal Flahertie O'Reilly is going through personal upheavals as well. After mourning his deceased wife for decades, he's finally allowed a new woman into his life. But this budding courtship is not going over well with Kinky Kincaid, the doctors' housekeeper, who fears having her position usurped by O'Reilly's new flame.

Meanwhile, life goes on in Ballybucklebo. From a mysterious outbreak at the local school to a complicated swindle involving an unlucky race horse, the two doctors will need all of their combined wit and compassion to put things right again—just in time for their lives to change forever.