A hired killer on his final job, a burned-out detective whose wife is dying slowly and in agony, a young boy abandoned by his parents and living alone by his wits. Three people, solitary and sundered from society.

In what is at one and the same time a coming-of-age novel, a realistic crime novel and a novel of the contemporary Southwest, The Killer Is Dying is above all the story of three men of vastly different age and background, and of the shape their lives take against the unforgiving sunlight and sprawl of America's fifth largest city, Phoenix.

The detective, Sayles, is looking for the killer, Christian, though he doesn't know that. Christian is trying to find the man who stepped in and took down his target before he had the chance. And the boy, Jimmie, is having the killer's dreams. While they never meet, through the course of the novel, all find community.